External Databases

• National Cancer Database: Established by American Collge of Surgeons as well as American Cancer Society, it is a clinical oncology database and is used to analyze data to track patients with malignant diseases, thier treatments ond outcomes.
• The Cancer Genome Atlas Program: A joint effort between NCI and National Human Genome Research Institute begun in 2006, it houses genomic, epigenoimic, transcriptomic and proteomic data to improve diagnosis, treatment and prevention of cancer.
• cBioPortal A portal for Cancer Genomics developed at Memorial Sloan Kettering Cancer Center.
• canSAR BLACK: The canSAR is an integrated knowledge base which incorporates molecular biology, chemistry, pharmacology, structural biology, networks, gene ontologies and clinical trial information. This database is very useful to those engaged in drug design, it will also be useful to identify whether a protein is a drug target, available bioactive compounds, structure, druggable based on structure information, ligand-based assessment and/or by network, enzyme, and whether mutation and RNA interference data are available.
• METABRIC: METABRIC, Molecular Taxonomy of Breast Cancer International Consortium comprises of clinical traits, expression, CNV profiles and SNP genotypes from breast pes derived from breast tumors from the participants of METABRIC trial. This is an integrated genomic/transcriptomic analysis of breast cancers for which long-termalong with clinical follow-up data. The discovery set was composed of 997 primary tumors and the data were validated in a second set of 995 tumors. The impact of germline variants (copy number variation CNV, and single-nucleotide polymorphisms, SNP) and somatic (CNA, copy number aberrations) on gene expression was analyzed
• The Cancer Imaging Archive (TCIA): A service which hosts a large archive of medical images of cancer available for public download. The data is organized as collections, based on a common disease , image modality or type and research focus.
• depmap portal: A portal to discover genetic and pharmacological dependencies, priotize tumor contexts and predictive biomarkers and explore over 2000 cancer models.